Selected Publications
1. Rinkevich Y, Walmsley GG, Hu MS, Maan ZN, Newman AM, Drukker M, Januszyk M, Krampitz GW, Gurtner GC, Lorenz HP, Weissman IL, Longaker MT. Skin fibrosis. Identification and isolation of a dermal lineage with intrinsic fibrogenic potential. Science. 2015 Apr 17;348(6232):aaa2151. doi: 10.1126/science.aaa2151. PMID: 25883361
2. Walmsley GG, Hu MS, Hong WX, Maan ZN, Lorenz HP, Longaker MT. A mouse fetal skin model of scarless wound repair. J Vis Exp. 2015 Jan 16;(95):52297. doi: 10.3791/52297. PMID: 25650841
3. Walmsley GG, Rinkevich Y, Hu MS, Montoro DT, Lo DD, McArdle A, Maan ZN, Morrison SD, Duscher D, Whittam AJ, Wong VW, Weissman IL, Gurtner GC, Longaker MT. Live fibroblast harvest reveals surface marker shift in vitro. Tissue Eng Part C Methods. 2015 Mar;21(3):314-21. doi: 10.1089/ten.TEC.2014.0118. Epub 2014 Dec 17. PMID: 25275778
1. Rinkevich Y, Walmsley GG, Hu MS, Maan ZN, Newman AM, Drukker M, Januszyk M, Krampitz GW, Gurtner GC, Lorenz HP, Weissman IL, Longaker MT. Skin fibrosis. Identification and isolation of a dermal lineage with intrinsic fibrogenic potential. Science. 2015 Apr 17;348(6232):aaa2151. doi: 10.1126/science.aaa2151. PMID: 25883361
2. Walmsley GG, Hu MS, Hong WX, Maan ZN, Lorenz HP, Longaker MT. A mouse fetal skin model of scarless wound repair. J Vis Exp. 2015 Jan 16;(95):52297. doi: 10.3791/52297. PMID: 25650841
3. Walmsley GG, Rinkevich Y, Hu MS, Montoro DT, Lo DD, McArdle A, Maan ZN, Morrison SD, Duscher D, Whittam AJ, Wong VW, Weissman IL, Gurtner GC, Longaker MT. Live fibroblast harvest reveals surface marker shift in vitro. Tissue Eng Part C Methods. 2015 Mar;21(3):314-21. doi: 10.1089/ten.TEC.2014.0118. Epub 2014 Dec 17. PMID: 25275778
Approximately six million Americans suffer from poor cutaneous wound healing (e.g. diabetic wounds, pressure wounds) annually, with 1.1 to 1.8 million new cases arising each year. It is estimated that we spend over $20 billion annually in wound care for these patients. Further, fibroses throughout the body are estimated to be responsible for 45% of all deaths in the U.S. Fibrosis can develop in any organ, often with devastating effects. Of patients who undergo abdominal surgery, 93% will develop abdominal adhesions, or bands of fibrous tissue that form between organs and the abdominal wall. From 1998 to 2002, 18.1% of hospitalizations were related to abdominal adhesions, resulting in an estimated cost of $1.18 billion annually. Unfortunately, there are limited means to prevent or treat fibroses such as scars and adhesions, or their sequelae.

Selected Publications
Approximately six million Americans suffer from poor cutaneous wound healing (e.g. diabetic wounds, pressure wounds) annually, with 1.1 to 1.8 million new cases arising each year. It is estimated that we spend over $20 billion annually in wound care for these patients. Further, fibroses throughout the body are estimated to be responsible for 45% of all deaths in the U.S. Fibrosis can develop in any organ, often with devastating effects. Of patients who undergo abdominal surgery, 93% will develop abdominal adhesions, or bands of fibrous tissue that form between organs and the abdominal wall. From 1998 to 2002, 18.1% of hospitalizations were related to abdominal adhesions, resulting in an estimated cost of $1.18 billion annually. Unfortunately, there are limited means to prevent or treat fibroses such as scars and adhesions, or their sequelae.
We hope to characterize and develop therapies to minimize and even prevent the development of scar tissue that develops in the skin, abdomen, and other sites, thereby addressing the clinical and financial burdens related to wound healing and fibrosis.
We currently have projects in the following areas, and collaborate with other laboratories to develop and test novel small molecule therapies, three-dimensional hydrogels to deliver cells and therapies, and disease models:

Wound Healing and Fibrosis
